This presentation explores the do's and don'ts of microalgae development. It covers business aspects, strain selection, GMO considerations, and associated risks. Inputs (water, nutrients), outputs, and the culture process (light, automation, CO₂) are highlighted, alongside bioreactor setup. The biorefinery concept for microalgae valorization is explained, emphasizing efficiency and sustainability. Concluding with key do's and don'ts, it provides actionable insights for the sector.