The presentation focuses on *Cyanotoxins and pigments with anticancer and antiobesity potential*, discussing why cyanobacteria are a valuable source of bioactive compounds. It examines molecules of interest, such as Nocuolin A, which has shown efficacy on real tumors, and Portoamides. Additionally, chlorophyll derivatives with lipid-reducing activities are highlighted. The use of thermal proteome profiling to investigate these compounds’ mechanisms of action is explored, concluding with the promising future of cyanobacterial compounds in cancer and obesity treatments.